Sodium Hydroxide → 3-[4-[2-(biphenyl-4-carbonylamino)ethoxy]phenyl]-2-(N-ethyl-N-phenylamino)propionic acid

HRID 1859934Notes

Reaction equation

HRID 1859934 reaction equation
[C:1]1([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH:6]=[CH:5][C:4]([C:7]([NH:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH:20]([N:26]([CH2:33][CH3:34])[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:21]([O:23]CC)=[O:22])=[CH:15][CH:14]=2)=[O:8])=[CH:3][CH:2]=1.[OH-].[Na+]>CO>[C:1]1([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH:2]=[CH:3][C:4]([C:7]([NH:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH:20]([N:26]([CH2:33][CH3:34])[C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[C:21]([OH:23])=[O:22])=[CH:15][CH:14]=2)=[O:8])=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18625935Ethyl 3-[4-[2-(biphenyl-4-carbonylamino)ethoxy]phenyl]-2-(N-ethyl-N-phenylamino)propionate

Product 1

HCID 186258163-[4-[2-(biphenyl-4-carbonylamino)ethoxy]phenyl]-2-(N-ethyl-N-phenylamino)propionic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 3-[4-[2-(biphenyl-4-carbonylamino)ethoxy]phenyl]-2-(N-ethyl-N-phenylamino)propionate, which is the product of Example 181, is hydrolyzed by sodium hydroxide in methanol to give the title compound.

Sources & evidence

ORD record
ord-fbec062901c84397ad771effe62df0ac
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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