Sodium Hydroxide → 3-[4-[2-(Biphenyl-4-carbonylamino)ethoxy]phenyl]-2-(N,N-diethylamino)propionic acid

HRID 1859937Notes

Reaction equation

HRID 1859937 reaction equation
[CH2:1]([N:3]([CH:6]([CH2:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][NH:22][C:23](=[O:36])[C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[CH:26][CH:25]=2)=[CH:15][CH:14]=1)[C:7]([O:9]CC)=[O:8])[CH2:4][CH3:5])[CH3:2].[OH-].[Na+]>CO>[C:27]1([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:26]=[CH:25][C:24]([C:23]([NH:22][CH2:21][CH2:20][O:19][C:16]2[CH:17]=[CH:18][C:13]([CH2:12][CH:6]([N:3]([CH2:4][CH3:5])[CH2:1][CH3:2])[C:7]([OH:9])=[O:8])=[CH:14][CH:15]=2)=[O:36])=[CH:29][CH:28]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18625914Ethyl 2-(N,N-diethylamino)-3-[4-[2-(4-phenylbenzoylamino)ethoxy]phenyl]propionate

Product 1

HCID 186259923-[4-[2-(Biphenyl-4-carbonylamino)ethoxy]phenyl]-2-(N,N-diethylamino)propionic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 2-(N,N-diethylamino)-3-[4-[2-(4-phenylbenzoylamino)ethoxy]phenyl]-propionate, which is the product of Example 189, is hydrolyzed by sodium hydroxide in methanol to give the title compound.

Sources & evidence

ORD record
ord-d374ad7343cb41d4a5381b401a58d96b
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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