Sodium Hydroxide → 3-[4-[2-(4-Pyridine-2-ylbenzoylamino)ethoxy]phenyl]-2-(pyrrole-1-yl)propionic acid

HRID 1859938Notes

Reaction equation

HRID 1859938 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:36]=[CH:35][C:10]([C:11]([NH:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][CH:24]([N:30]3[CH:34]=[CH:33][CH:32]=[CH:31]3)[C:25]([O:27]CC)=[O:26])=[CH:19][CH:18]=2)=[O:12])=[CH:9][CH:8]=1.[OH-].[Na+]>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][C:10]([C:11]([NH:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][CH:24]([N:30]3[CH:31]=[CH:32][CH:33]=[CH:34]3)[C:25]([OH:27])=[O:26])=[CH:19][CH:18]=2)=[O:12])=[CH:35][CH:36]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18626034Ethyl 3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]-2-(pyrrole-1-yl)propionate

Product 1

HCID 186258053-[4-[2-(4-Pyridine-2-ylbenzoylamino)ethoxy]phenyl]-2-(pyrrole-1-yl)propionic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]-2-(pyrrole-1-yl)propionate, which is the product of Example 191, is hydrolyzed by sodium hydroxide in methanol to give the title compound.

Sources & evidence

ORD record
ord-51fbdc736a054ccf88dde14b0161de54
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

Loading…