Ethyl 3-(4-benzyloxyphenyl)-2-phenoxypropionate → Ethyl 3-(4-hydroxyphenyl)-2-phenoxypropionate

HRID 1859956Notes

Reaction equation

HRID 1859956 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([O:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd]>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH:16]([O:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:13][CH:14]=1

Participants

3

Reactant 1

HCID 18625773Ethyl 3-(4-benzyloxyphenyl)-2-phenoxypropionate

Product 1

HCID 18625748Ethyl 3-(4-hydroxyphenyl)-2-phenoxypropionateYield 63.2%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In a similar manner to that described in Reference example 1(d), a reaction was carried out using ethyl 3-(4-benzyloxyphenyl)-2-phenoxypropionate (2.10 g), which is the product of Reference example 4(b) and palladium on carbon (5%, 0.32 g) and the reaction mixture was treated to afford the desired compound (1.01 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-6775c484f60d40c6a753d9aba90c1b03
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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