Diethyl 2-(4-benzyloxybenzyl)-2-(4-isopropylphenoxy)malonate → Diethyl 2-(4-hydroxyphenyl)-2-(4-isopropylphenoxy)malonate

HRID 1859964Notes

Reaction equation

HRID 1859964 reaction equation
C(OC1C=CC(C[C:14]([O:25][C:26]2[CH:31]=[CH:30][C:29]([CH:32]([CH3:34])[CH3:33])=[CH:28][CH:27]=2)([C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:15]([O:17][CH2:18][CH3:19])=[O:16])=CC=1)C1C=CC=CC=1>[Pd]>[OH:25][C:26]1[CH:31]=[CH:30][C:29]([C:14]([O:25][C:26]2[CH:31]=[CH:30][C:29]([CH:32]([CH3:33])[CH3:34])=[CH:28][CH:27]=2)([C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:28][CH:27]=1

Participants

3

Reactant 1

HCID 18625725Diethyl 2-(4-benzyloxybenzyl)-2-(4-isopropylphenoxy)malonate

Product 1

HCID 18625710Diethyl 2-(4-hydroxyphenyl)-2-(4-isopropylphenoxy)malonateYield 198.1%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In a similar manner to that described in Reference example 1(d), a reaction was carried out using diethyl 2-(4-benzyloxybenzyl)-2-(4-isopropylphenoxy)malonate (32.3 g), which is the product of Reference example 5(b), and palladium on carbon (5%, 2.00 g) and the reaction mixture was treated to afford the desired compound (25.2 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-04acd95af4a64d7b9091d5b61e95697b
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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