Methanesulfonyl chloride → HCID 18625791, compound

HRID 1859968Notes

Reaction equation

HRID 1859968 reaction equation
[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([O:18][C:19]2[CH:24]=[CH:23][C:22]([CH:25]([CH3:27])[CH3:26])=[CH:21][CH:20]=2)[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:7][CH:6]=1.[CH3:28][S:29](Cl)(=[O:31])=[O:30]>C(N(CC)CC)C>[CH:25]([C:22]1[CH:21]=[CH:20][C:19]([O:18][CH:12]([CH2:11][C:8]2[CH:7]=[CH:6][C:5]([O:4][CH2:3][CH2:2][O:1][S:29]([CH3:28])(=[O:31])=[O:30])=[CH:10][CH:9]=2)[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:24][CH:23]=1)([CH3:26])[CH3:27]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 18625717HCID 18625717, compound

Product 1

HCID 18625791HCID 18625791, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In a similar manner to that described in Reference example 3 (g), a reaction was carried out using ethyl 3-[4-(2-hydroxyethoxy)phenyl]-2-(4-isopropylphenoxy)propionate (16.2 g), which is the product of Reference example 5(f), triethylamine (12.1 ml) and methanesulfonyl chloride (5.05 ml) and the reaction mixture was treated to afford the desired compound (19.6 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-d8451e34f3ff4e61a4eeff02af7f0b70
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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