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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1859974Generated: October 30, 2026

Methanesulfonyl chloride → Ethyl 2-butyl-3-[4-(2-methanesulfonyloxyethoxy)phenyl]propionate

https://huagongshe.com/reaction/1859974

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanesulfonyl chlorideHCID 31297—
ReactantEthyl 2-butyl-3-[4-(2-hydroxyethoxy)phenyl]propionateHCID 18625693—
SolventTriethylamineHCID 8471—
ProductEthyl 2-butyl-3-[4-(2-methanesulfonyloxyethoxy)phenyl]propionateHCID 18625769—

Reaction Steps

In a similar manner to that described in Reference example 3(g), a reaction was carried out using ethyl 2-butyl-3-[4-(2-hydroxyethoxy)phenyl]propionate (1.44 g), which is the product of Reference example 6(e), triethylamine (2.04 ml) and methanesulfonyl chloride (0.76 ml) and the reaction mixture was treated to afford the desired compound (1.65 g) as a syrup.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06528525B1
Source datasetuspto-grants-2003_03
ORD IDord-0528bfaa25d4464db8d6cb6101bba95a
Source noteuspto-grants-2003_03