Methanesulfonyl chloride → Ethyl 2-butyl-3-[4-(2-methanesulfonyloxyethoxy)phenyl]propionate

HRID 1859974Notes

Reaction equation

HRID 1859974 reaction equation
[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][OH:21])=[CH:14][CH:13]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:2][CH2:3][CH3:4].[CH3:22][S:23](Cl)(=[O:25])=[O:24]>C(N(CC)CC)C>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][O:21][S:23]([CH3:22])(=[O:25])=[O:24])=[CH:14][CH:13]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 18625693Ethyl 2-butyl-3-[4-(2-hydroxyethoxy)phenyl]propionate

Product 1

HCID 18625769Ethyl 2-butyl-3-[4-(2-methanesulfonyloxyethoxy)phenyl]propionate

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In a similar manner to that described in Reference example 3(g), a reaction was carried out using ethyl 2-butyl-3-[4-(2-hydroxyethoxy)phenyl]propionate (1.44 g), which is the product of Reference example 6(e), triethylamine (2.04 ml) and methanesulfonyl chloride (0.76 ml) and the reaction mixture was treated to afford the desired compound (1.65 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-0528bfaa25d4464db8d6cb6101bba95a
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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