Methanesulfonyl chloride → HCID 18625951, compound

HRID 1859983Notes

Reaction equation

HRID 1859983 reaction equation
[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([CH3:27])([CH2:18][CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:7][CH:6]=1.[CH3:28][S:29](Cl)(=[O:31])=[O:30]>C(N(CC)CC)C>[CH3:28][S:29]([O:1][CH2:2][CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:11][C:12]([CH3:27])([CH2:18][CH2:19][CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:9][CH:10]=1)(=[O:31])=[O:30]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 18625707HCID 18625707, compound

Product 1

HCID 18625951HCID 18625951, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In a similar manner to that described in Reference example 3(g), a reaction was carried out using ethyl 3-[4-(2-hydroxyethoxy)phenyl]-2-methyl-2-(3-phenylpropyl)propionate (0.95 g), which is the product of Reference example 7(f), triethylamine (1.07 ml) and methanesulfonyl chloride (0.40 ml) and the reaction mixture was treated to afford the desired compound (1.16 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-16c86c27c1b54769a6eecf12283acfb9
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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