HCID 12134925, compound → Ethyl 3-(4-hydroxyphenyl)-2-methyl-2-phenoxypropionate

HRID 1859987Notes

Reaction equation

HRID 1859987 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([CH3:29])([O:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd]>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][C:16]([CH3:29])([O:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:13][CH:14]=1

Participants

3

Reactant 1

HCID 12134925HCID 12134925, compound

Product 1

HCID 11220314Ethyl 3-(4-hydroxyphenyl)-2-methyl-2-phenoxypropionateYield 100.7%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In a similar manner to that described in Reference example 1(d), a reaction was carried out using ethyl 3-(4-benzyloxyphenyl)-2-methyl-2-phenoxypropionate (4.97 g), which is the product of Reference example 8(a), and palladium on carbon (5%, 0.75 g) and the reaction mixture was treated to afford the desired compound (3.85 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-d67f2987edf44b7ca13b021ec5256b3f
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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