Methanesulfonyl chloride → HCID 18625834, compound

HRID 1859990Notes

Reaction equation

HRID 1859990 reaction equation
[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([CH3:25])([O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:7][CH:6]=1.[CH3:26][S:27](Cl)(=[O:29])=[O:28]>C(N(CC)CC)C>[CH3:26][S:27]([O:1][CH2:2][CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:11][C:12]([CH3:25])([O:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:9][CH:10]=1)(=[O:29])=[O:28]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 18625750HCID 18625750, compound

Product 1

HCID 18625834HCID 18625834, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In a similar manner to that described in Reference example 3(g), a reaction was carried out using ethyl 3-[4-(2-hydroxyethoxy)phenyl]-2-methyl-2-phenoxypropionate (1.10 g), which is the product of Reference example 8(d), triethylamine (0.49 ml) and methanesulfonyl chloride (0.25 ml) and the reaction mixture was treated to afford the desired compound (1.42 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-fc7ee822e7be4b118b134a8285c71a02
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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