Methanesulfonyl chloride → HCID 18625923, compound

HRID 1859997Notes

Reaction equation

HRID 1859997 reaction equation
[CH:1]([C:4]1[CH:28]=[CH:27][C:7]([O:8][C:9]([CH3:26])([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][OH:25])=[CH:18][CH:17]=2)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[CH3:29][S:30](Cl)(=[O:32])=[O:31]>C(N(CC)CC)C>[CH:1]([C:4]1[CH:28]=[CH:27][C:7]([O:8][C:9]([CH3:26])([CH2:15][C:16]2[CH:17]=[CH:18][C:19]([O:22][CH2:23][CH2:24][O:25][S:30]([CH3:29])(=[O:32])=[O:31])=[CH:20][CH:21]=2)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:6][CH:5]=1)([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 18625988HCID 18625988, compound

Product 1

HCID 18625923HCID 18625923, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In a similar manner to that described in Reference example 3(g), a reaction was carried out using ethyl 2-(4-isopropylphenoxy)-3-[4-(2-hydroxyethoxy)phenyl]-2-methylpropionate (0.66 g), which is the product of Reference example 9(d), triethylamine (0.36 ml) and methanesulfonyl chloride (0.15 ml) and the reaction mixture was treated to afford the desired compound (0.64 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-12c9480adf0949bf92068bb16eec6d97
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

Loading…