Sodium Hydroxide → 3'-Methoxymethoxymethylbiphenyl-4-carboxylic acid

HRID 1860017Notes

Reaction equation

HRID 1860017 reaction equation
[CH3:1][O:2][CH2:3][O:4][CH2:5][C:6]1[CH:7]=[C:8]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([O:20]C)=[O:19])=[CH:14][CH:13]=2)[CH:9]=[CH:10][CH:11]=1.[OH-].[Na+]>>[CH3:1][O:2][CH2:3][O:4][CH2:5][C:6]1[CH:7]=[C:8]([C:12]2[CH:13]=[CH:14][C:15]([C:18]([OH:20])=[O:19])=[CH:16][CH:17]=2)[CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625885Methyl 3'-methoxymethoxymethylbiphenyl-4-carboxylate

Product 1

HCID 186260473'-Methoxymethoxymethylbiphenyl-4-carboxylic acidYield 80.8%

Procedure

In a similar manner to that described in Example 2, a reaction was carried out using methyl 3′-methoxymethoxymethylbiphenyl-4-carboxylate (445 mg), which is the product of Reference example 15(b), and aqueous sodium hydroxide (1N, 3.10 ml) and the reaction mixture was treated to afford the desired compound (342 mg) as colorless crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-40ff700d5bf94b92863678211224df37
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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