Sodium Hydroxide → 4-(2-hydroxyphenyl)benzoic Acid

HRID 1860020Notes

Reaction equation

HRID 1860020 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([C:14]([O:16]C)=[O:15])=[CH:10][CH:9]=1.[OH-].[Na+]>>[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 45648562-(4-Methoxycarbonylphenyl)phenol

Product 1

HCID 106562444-(2-hydroxyphenyl)benzoic AcidYield 92.9%

Procedure

In a similar manner to that described in Example 2, a reaction was carried out using methyl 2′-hydroxybiphenyl-4-carboxylate (498 mg) and aqueous sodium hydroxide (1N, 4.81 ml) and the reaction mixture was treated to afford the title compound (434 mg) as colorless crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-340d1ef9824643168ccac76c4eb8a5ab
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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