Sodium Hydroxide → 4'-Methoxymethoxy-3',5'-dimethylbiphenyl-4-carboxylic acid

HRID 1860021Notes

Reaction equation

HRID 1860021 reaction equation
[CH3:1][O:2][CH2:3][O:4][C:5]1[C:10]([CH3:11])=[CH:9][C:8]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([O:20]C)=[O:19])=[CH:14][CH:13]=2)=[CH:7][C:6]=1[CH3:22].[OH-].[Na+]>>[CH3:1][O:2][CH2:3][O:4][C:5]1[C:10]([CH3:11])=[CH:9][C:8]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([OH:20])=[O:19])=[CH:14][CH:13]=2)=[CH:7][C:6]=1[CH3:22]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625974Methyl 4'-methoxymethoxy-3',5'-dimethylbiphenyl-4-carboxylate

Product 1

HCID 186257084'-Methoxymethoxy-3',5'-dimethylbiphenyl-4-carboxylic acidYield 83.7%

Procedure

In a similar manner to that described in Example 2, a reaction was carried out using methyl 4′-methoxymethoxy-3′,5′-dimethylbiphenyl-4-carboxylate (1.24 g) and aqueous sodium hydroxide (1N, 8.20 ml) and the reaction mixture was treated to afford the desired compound (0.99 g) as colorless crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-eb415a7c1833460a88234ec39342e51a
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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