Sodium Hydroxide → 6-[(Propan-2-yl)oxy]pyridine-3-carboxylic acid

HRID 1860024Notes

Reaction equation

HRID 1860024 reaction equation
[CH:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]([C:9]([O:11]C(C)C)=[O:10])=[CH:7][N:6]=1)([CH3:3])[CH3:2].[OH-].[Na+]>>[CH:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]([C:9]([OH:11])=[O:10])=[CH:7][N:6]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 186258531-Methylethyl 6-(1-methylethoxy)-3-pyridinecarboxylate

Product 1

HCID 186257386-[(Propan-2-yl)oxy]pyridine-3-carboxylic acidYield 100.5%

Procedure

In a similar manner to that described in Example 2, a reaction was carried out using isopropyl 6-isopropoxynicotinate (130 mg), which is the product of Reference example 18(a) and aqueous sodium hydroxide solution (1N, 0.87 ml) and the reaction mixture was treated to afford the title compound (106 mg) as crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-831b9ce2d6f041a8830776380c06becd
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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