Potassium Hydroxide → 3-(4-Benzyloxyphenyl)-2-propylpropionic acid

HRID 1860032Notes

Reaction equation

HRID 1860032 reaction equation
[CH2:1]([O:8][C:9]1[CH:29]=[CH:28][C:12]([CH2:13][C:14]([CH2:25][CH2:26][CH3:27])(C(OCC)=O)[C:15]([O:17]CC)=[O:16])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+]>>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:13][CH:14]([CH2:25][CH2:26][CH3:27])[C:15]([OH:17])=[O:16])=[CH:28][CH:29]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 18625701Diethyl 2-(4-benzyloxybenzyl)-2-propylmalonate

Product 1

HCID 186259903-(4-Benzyloxyphenyl)-2-propylpropionic acidYield 53.7%

Procedure

In a similar manner to that described in Reference example 2(b), a reaction was carried out using diethyl 2-(4-benzyloxybenzyl)-2-propylmalonate (9.85 g), which is the product of Reference example 23(a), and potassium hydroxide (5.25 g) and the reaction mixture was treated to afford the desired compound (3.96 g) as brown crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-3f1237843b184b37b9928155e7c0cbe1
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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