Sodium Hydroxide → 6-(4-Methoxyphenyl)pyridine-3-carboxylic acid

HRID 1860036Notes

Reaction equation

HRID 1860036 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15]C)=[O:14])=[CH:11][N:10]=2)=[CH:5][CH:4]=1.[OH-].[Na+]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:18]=[CH:17][C:12]([C:13]([OH:15])=[O:14])=[CH:11][N:10]=2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625729HCID 18625729, compound

Product 1

HCID 186259336-(4-Methoxyphenyl)pyridine-3-carboxylic acidYield 70.7%

Procedure

In a similar manner to that described in Example 2, a reaction was carried out using methyl 6-(4-methoxyphenyl)nicotinate (3.95 g) and aqueous sodium hydroxide solution (1N, 32.5 ml) and the reaction mixture was treated to afford the title compound (2.63 g) as colorless crystals.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-e70ca072ff05452e8dda5e203b16360c
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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