Sodium Hydroxide → 2-(5-Nitropyridin-2-yl)benzoic acid

HRID 1860054Notes

Reaction equation

HRID 1860054 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][C:7]([C:10]2[CH:19]=[CH:18][CH:17]=[CH:16][C:11]=2[C:12]([O:14]C)=[O:13])=[CH:8][CH:9]=1)([O-:3])=[O:2].[OH-].[Na+]>>[N+:1]([C:4]1[CH:5]=[N:6][C:7]([C:10]2[CH:19]=[CH:18][CH:17]=[CH:16][C:11]=2[C:12]([OH:14])=[O:13])=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625779HCID 18625779, compound

Product 1

HCID 186260112-(5-Nitropyridin-2-yl)benzoic acidYield 71.8%

Procedure

In a similar manner to that described in Example 2, a reaction was carried out using methyl 3-nitropyridine-6-ylbenzoate (545 mg), which is the product of Reference example 32(a), and aqueous sodium hydroxide solution (1N, 3.16 ml) at 90° C. and the reaction mixture was treated to afford the title compound (370 mg) as colorless crystals.

Workup

  1. customat 90° C.
  2. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-2953243639a24c4dbaeffcbfdcc9be20
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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