Ethyl 3-(4-benzyloxyphenyl)-2-(4-methylphenoxy)propionate → Ethyl 3-(4-hydroxyphenyl)-2-(4-methylphenoxy)propionate

HRID 1860060Notes

Reaction equation

HRID 1860060 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([O:22][C:23]2[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][CH:24]=2)[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd]>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([O:22][C:23]2[CH:24]=[CH:25][C:26]([CH3:29])=[CH:27][CH:28]=2)[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=1

Participants

3

Reactant 1

HCID 18625971Ethyl 3-(4-benzyloxyphenyl)-2-(4-methylphenoxy)propionate

Product 1

HCID 18626029Ethyl 3-(4-hydroxyphenyl)-2-(4-methylphenoxy)propionateYield 103.9%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In a similar manner to that described in Reference example 1(d), a reaction was carried out using ethyl 3-(4-benzyloxyphenyl)-2-(4-methylphenoxy)propionate (2.84 g), which is the product of Reference example 35(b), and palladium on carbon (284 mg) and the reaction mixture was treated to afford the desired compound (2.27 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-4a4b0b236bc4468495f668469663b16c
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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