Potassium Carbonate → HCID 18625796, compound

HRID 1860067Notes

Reaction equation

HRID 1860067 reaction equation
[F:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][CH:7]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:4][CH:3]=1.Br[CH2:24][CH2:25][O:26][CH:27]1[CH2:32][CH2:31][CH2:30][CH2:29][O:28]1.C(=O)([O-])[O-].[K+].[K+]>>[F:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][CH:7]([CH2:13][C:14]2[CH:15]=[CH:16][C:17]([O:20][CH2:24][CH2:25][O:26][CH:27]3[CH2:32][CH2:31][CH2:30][CH2:29][O:28]3)=[CH:18][CH:19]=2)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 866212-(2-Bromoethoxy)tetrahydro-2H-pyranHCID 18625989HCID 18625989, compound

Product 1

HCID 18625796HCID 18625796, compoundYield 96%

Procedure

In a similar manner to that described in Reference example 3(e), a reaction was carried out using ethyl 2-(4-fluorophenoxy)-3-(4-hydroxyphenyl)propionate (2.75 g), which is the product of Reference example 37(b), 2-(2-bromoethyoxy)tetrahydropyran (2.08 g)and potassium carbonate (3.75 g) and the reaction mixture was treated to afford the desired compound (3.75 g) as a colorless oil.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-606f35a62a624c3999c93050affdded1
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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