Methanesulfonyl chloride → HCID 18625859, compound

HRID 1860069Notes

Reaction equation

HRID 1860069 reaction equation
[F:1][C:2]1[CH:25]=[CH:24][C:5]([O:6][CH:7]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][OH:23])=[CH:16][CH:15]=2)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:4][CH:3]=1.[CH3:26][S:27](Cl)(=[O:29])=[O:28]>C(N(CC)CC)C>[F:1][C:2]1[CH:25]=[CH:24][C:5]([O:6][CH:7]([CH2:13][C:14]2[CH:15]=[CH:16][C:17]([O:20][CH2:21][CH2:22][O:23][S:27]([CH3:26])(=[O:29])=[O:28])=[CH:18][CH:19]=2)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 18625829HCID 18625829, compound

Product 1

HCID 18625859HCID 18625859, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In a similar manner to that described in Reference example 3(g), a reaction was carried out using ethyl 2-(4-fluorophenoxy)-3-[4-(2-hydroxyethoxy)phenyl]propionate (2.68 g), which is the product of Reference example 37(d), triethylamine (1.61 ml) and methanesulfonyl chloride (0.65 ml) and the reaction mixture was treated to afford the desired compound (3.17 g) as a pale yellow oil.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-428c1b5979f049b2b9410d1289840369
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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