Potassium Carbonate → HCID 18626015, compound

HRID 1860085Notes

Reaction equation

HRID 1860085 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:16][C:17]2[CH:22]=[CH:21][C:20]([CH:23]([CH3:25])[CH3:24])=[CH:19][CH:18]=2)([CH3:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1.CS(O[CH2:31][CH2:32][NH:33][C:34](=[O:40])[O:35][C:36]([CH3:39])([CH3:38])[CH3:37])(=O)=O.C(=O)([O-])[O-].[K+].[K+]>>[C:36]([O:35][C:34]([NH:33][CH2:32][CH2:31][O:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:16][C:17]2[CH:18]=[CH:19][C:20]([CH:23]([CH3:24])[CH3:25])=[CH:21][CH:22]=2)([CH3:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1)=[O:40])([CH3:39])([CH3:38])[CH3:37]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 18626008HCID 18626008, compoundHCID 22605302tert-Butyl N-(2-((methylsulfonyl)oxy)ethyl)carbamate

Product 1

HCID 18626015HCID 18626015, compoundYield 90.6%

Procedure

In a similar manner to that described in Reference example 25, a reaction was carried out using ethyl 3-(4-hydroxyphenyl)-2-(4-isopropylphenoxy)-2-methylpropionate (4.85 g), which is the product of Reference example 9(b), t-butyl 2-methanesulfonyloxy-ethylcarbamate (8.47 g) and potassium carbonate (9.78 g) and the reaction mixture was treated to afford the title compound (6.23 g) as a colorless oil.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-129939dddd614322b46aa1bc7a85a3fb
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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