反应详情

Triethylamine (0.14 ml) was added to a suspension of 4-pyridine-2-ylbenzoylchloride hydrochloride (254 mg) in dichloromethane (2 ml). To the mixture a solution of ethanolamine (0.060 ml) in dichloromethane (3 ml) was added. This mixture was stirred for 30 minutes. At the end of this time the reaction mixture was concentrated and the residue was partitioned between ethyl acetate and water. The ethyl acetate layer was separated and washed with aqueous sodium chloride and dried over anhydrous magnesium sulfate and concentrated to afford crystals. The crystals were washed with isopropyl ether to afford the title compound (111 mg).

1. concentrationAt the end of this time the reaction mixture was concentrated
2. customthe residue was partitioned between ethyl acetate and water
3. customThe ethyl acetate layer was separated
4. washwashed with aqueous sodium chloride
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated
7. customto afford crystals
8. washThe crystals were washed with isopropyl ether