Piperidine → HCID 10740172, compound

HRID 1860444Notes

Reaction equation

[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:10][CH:9]1[CH2:21][O:22][C:23](OC1C=CC=CC=1)=[O:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:32]1[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1>>[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:10][CH:9]1[CH2:21][O:22][C:23]([N:32]1[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1)=[O:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 8082Piperidine

HCID 11373410HCID 11373410, compound

Product 1

HCID 10740172HCID 10740172, compoundYield 66.5%

Procedure

Working again according to a protocol identical to the one used in step 1.1 of Example 1, followed by treating, under the same conditions as those of step 1.2 of Example 1, 1 g of 1,4-dibenzyl-2-phenoxycarbonyloxymethylpiperazine with 10 ml de piperidine, 0.68 g of 1,4-dibenzyl-2-(1′-piperidinocarbonyloxymethyl)piperazine is obtained in the form of a viscous product. Yield: 66.5%. Rf=0.09 (70/30 v/v ether/petroleum ether).

Sources & evidence

ORD record: ord-f9908d8baf66463fbed1c9e603b5312b
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06531476B1

Reaction notes

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