Benzoyl chloride, 3,4,5-trimethoxy- → HCID 461346, compound

HRID 1860445Notes

Reaction equation

Cl.[N:2]1([C:8]([O:10][CH2:11][CH:12]2[CH2:17][NH:16][CH2:15][CH2:14][NH:13]2)=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[CH3:18][O:19][C:20]1[CH:21]=[C:22]([CH:26]=[C:27]([O:31][CH3:32])[C:28]=1[O:29][CH3:30])[C:23](Cl)=[O:24]>>[CH3:18][O:19][C:20]1[CH:21]=[C:22]([CH:26]=[C:27]([O:31][CH3:32])[C:28]=1[O:29][CH3:30])[C:23]([N:13]1[CH2:14][CH2:15][N:16]([C:23](=[O:24])[C:22]2[CH:21]=[C:20]([O:19][CH3:18])[C:28]([O:29][CH3:30])=[C:27]([O:31][CH3:32])[CH:26]=2)[CH2:17][CH:12]1[CH2:11][O:10][C:8]([N:2]1[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1)=[O:9])=[O:24]

Participants

Reactant 2

HCID 78282Benzoyl chloride, 3,4,5-trimethoxy-

HCID 18623795HCID 18623795, compound

Product 1

HCID 461346HCID 461346, compoundYield 68.5%

Procedure

Working again according to a protocol identical to the one used in step 1.3 of Example 1, followed by treating, under the same conditions as those of step 1.4 of Example 1, 0.5 g of 2-(1′-piperidinocarbonyloxymethyl)piperazine hydrochloride with 1.1 g of 3,4,5-trimethoxybenzoyl chloride, 0.8 g of 1,4-bis(3′,4′,5′-trimethoxybenzoyl)-2-(1′-piperidinocarbonyloxymethyl)piperazine is obtained. Yield: 56%. Melting point: 146.7° C.

Sources & evidence

ORD record: ord-ef6bc87305204fe3b48ac143f5d75e51
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06531476B1

Reaction notes

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