反应详情

温度

40 °C

2.44 g (6.43 mmol) of 1,4-dibenzyl-2-tert-butylcarbonylaminomethylpiperazine are dissolved in 50 ml of ethanol and 1 ml of 12N HCl in a 100-ml ground-necked round-bottomed flask. About 100 mg of palladium (10%) on charcoal are added thereto. The mixture is then placed under a hydrogen atmosphere, stirred vigorously and heated gently (40° C.) for 3 hours. The suspension is filtered on paper and the catalyst is rinsed several times with ethanol and water. The solvents are evaporated off to give 1.2 g of 2-tert-butylcarbonylaminomethylpiperazine hydrochloride. Yield: 68.6%. Melting point: 278.6° C. Rf=0.13 (80/20/[lacuna] v/v/v CHCl3/MeOH/NH4)OH).

1. filtrationThe suspension is filtered on paper
2. washthe catalyst is rinsed several times with ethanol and water
3. customThe solvents are evaporated off