HCID 12018679, compound → HCID 12018680, compound

HRID 1860519Notes

Reaction equation

HRID 1860519 reaction equation
[C:1]1([CH3:32])[CH:6]=[CH:5][C:4]([N:7]2[C:11]([NH2:12])=[CH:10][C:9]([C:13]3[CH:18]=[CH:17][C:16]([NH:19][S:20]([C:23]4[CH:28]=[CH:27][C:26]([N+:29]([O-])=O)=[CH:25][CH:24]=4)(=[O:22])=[O:21])=[CH:15][CH:14]=3)=[N:8]2)=[CH:3][CH:2]=1.[H][H]>CCOC(C)=O.[Pd]>[C:1]1([CH3:32])[CH:2]=[CH:3][C:4]([N:7]2[C:11]([NH2:12])=[CH:10][C:9]([C:13]3[CH:14]=[CH:15][C:16]([NH:19][S:20]([C:23]4[CH:28]=[CH:27][C:26]([NH2:29])=[CH:25][CH:24]=4)(=[O:21])=[O:22])=[CH:17][CH:18]=3)=[N:8]2)=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 12018679HCID 12018679, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 12018680HCID 12018680, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 1-(4-tolyl)-3-(4′-(4-nitrophenyl)sulfonylamino phenyl)-5-aminopyrazole (0.8 g, 1.8 mmol) in EtOAc (30 mL) at room temperature was added 10% Pd-C (0.2 g). The mixture was treated with hydrogen gas at 30 psi for 4 h on a Parr shaker. The mixture was filtered through Celite and the solvent evaporated to yield 1-(4-tolyl)-3-(4′-(4-aminophenyl)sulfonylamino phenyl)-5-aminopyrazole as a solid, which was used without further purification.

Workup

  1. filtrationThe mixture was filtered through Celite
  2. customthe solvent evaporated

Sources & evidence

ORD record
ord-45a57212799e404c839525a4f910dc9d
Source dataset
uspto-grants-2003_03
Patent number
US06531478B2

Reaction notes

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