ethyl 1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate → HCID 9835275, compound

HRID 1860538Notes

Reaction equation

HRID 1860538 reaction equation
C(OC(C1CCC2C(=CC=CC=2)C1=O)=O)C.C(OC(C1CCC2C(=CC=C(Cl)C=2)C1=O)=O)C.[OH:34][NH:35][C:36](=[O:54])[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH:42]1[CH2:51][CH2:50][C:49]2[C:44](=[CH:45][CH:46]=[C:47](Cl)[CH:48]=2)[C:43]1=[O:53]>>[OH:34][NH:35][C:36](=[O:54])[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH:42]1[CH2:51][CH2:50][C:49]2[C:44](=[CH:45][CH:46]=[CH:47][CH:48]=2)[C:43]1=[O:53]

Participants

4

Reactant 3

HCID 251472ethyl 1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylateHCID 21218215HCID 21218215, compoundHCID 229774506-(6-chloro-1-oxo-1,2,3,4-tetrahydro-naphthalen-2-yl)-hexanoic Acid Hydroxyamide

Product 1

HCID 9835275HCID 9835275, compound

Procedure

6-(1-oxo-1,2,3,4-tetrahydro-naphthalen-2-yl)-hexanoic acid hydroxyamide (5a) is prepared from 1-oxo-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid ethyl ester (1a) in an analogous manner to that described for the conversion of 3a to 3c in example 3. Yield in the last step is 10%, MS (APCI): 274.1 (M−1).

Workup

  1. customYield in the last step

Sources & evidence

ORD record
ord-7dc7e151016c40f5848c436cfe25d342
Source dataset
uspto-grants-2003_03
Patent number
US06531472B2

Reaction notes

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