HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → 2-(methylsulfonyl)-5-nitropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium methanesulfinate | HCID 2733271 | — |
| Reactant | 2-(Methylthio)-5-nitropyridine | HCID 4439313 | — |
| Product | 2-(methylsulfonyl)-5-nitropyridine | HCID 1211552 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
Alternatively, 3-nitro-6-(methylsulfonyl)pyridine was prepared by dissolving of 3-nitro-6-(methylthio)pyridine (1 equivalent) and sodium methane sulfinate in DMSO and heating at 100° C. for 2 hours. The reaction was diluted with a large excess of water and extracted with ethyl acetate. The organic layer was concentrated in vacuo to give the desired 3-nitro-6-(methylsulfonyl)pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06531492B1 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-5b9db740404c425fa5e386faaffa45a8 |
| Source note | uspto-grants-2003_03 |