反应详情

A mixture of the product of STEP 5 (0.525 g, 1.3 mmol), 20% Pd/C, triethylamine (0.39 g, 3.9 mmol) in ethanol was subjected to hydrogenation conditions at 40 psi and room temperature for 1 h. The reaction was filtered through a short column of Celite® and concentrated. The residue was purified by chromatography (on silica gel, ethyl acetate/hexane=1/3) to afford 0.19 g colorless oil. NMR spectra of the product were consistent for the proposed structure.

1. filtrationThe reaction was filtered through a short column of Celite®
2. concentrationconcentrated
3. customThe residue was purified by chromatography (on silica gel, ethyl acetate/hexane=1/3)