反应详情

A mixture of the product prepared in STEP 2 (5.8 g), ethylene glycol (15 mg) and KOH (5.6 g) was heated at 150 degrees for two days under nitrogen. The solution was cooled to room temperature and poured into 1% hydrochloric acid/water (200 ml). The aqueous portion was extracted well with ethyl acetate and the combined organic extract was washed with water, brine and dried over MgSO4. Solvent was removed to give the crude product that was used without further purification. The 1H NMR was consistent with the proposed structure.

1. temperaturewas heated at 150 degrees for two days under nitrogen
2. extractionThe aqueous portion was extracted well with ethyl acetate
3. extractionthe combined organic extract
4. washwas washed with water, brine
5. dry with materialdried over MgSO4
6. customSolvent was removed