HCID 18624195, compound → HCID 22978426, compound

HRID 1860683Notes

Reaction equation

HRID 1860683 reaction equation
[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]([CH2:7][C:8]([CH3:15])([CH:13]=[CH2:14])[CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.Cl.[CH2:19](O)[CH3:20]>>[CH2:19]([O:11][C:10](=[O:12])[CH2:9][C:8]([CH2:7][C:6]1[CH:16]=[CH:17][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)([CH3:15])[CH:13]=[CH2:14])[CH3:20]

Participants

3

Reactant 2

HCID 18624195HCID 18624195, compoundHCID 21887872Ethanol hydrochloride

Product 1

HCID 22978426HCID 22978426, compound

Procedure

A solution of product prepared in STEP 3 (5.6 g), saturated hydrochloric acid/ethanol (70 ml) was stirred at room temperature overnight. Solvent was removed. The crude product was purified on a silica gel column, eluting with 0.5% ethyl acetate/hexane to afford colorless oil (3.3 g). The 1H NMR was consistent with the proposed structure.

Workup

  1. customSolvent was removed
  2. customThe crude product was purified on a silica gel column
  3. washeluting with 0.5% ethyl acetate/hexane

Sources & evidence

ORD record
ord-88a7f40a5963421ab901ae6f04f9dbc9
Source dataset
uspto-grants-2003_03
Patent number
US06531494B1

Reaction notes

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