Dimethyl-3-nitrobiphenyl-4-malonate → 3-Nitro-biphenyl-4-acetic acid

HRID 1860722Notes

Reaction equation

HRID 1860722 reaction equation
C[O:2][C:3](=[O:24])[CH:4]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:11][C:10]=1[N+:21]([O-:23])=[O:22])C(OC)=O>Cl>[N+:21]([C:10]1[CH:11]=[C:12]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:13]=[CH:14][C:9]=1[CH2:4][C:3]([OH:24])=[O:2])([O-:23])=[O:22]

Participants

3

Reactant 1

HCID 10711410Dimethyl-3-nitrobiphenyl-4-malonate

Product 1

HCID 104913603-Nitro-biphenyl-4-acetic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Crude dimethyl-3-nitrobiphenyl-4-malonate was refluxed in 30 mL of 6 N hydrochloric acid for 24 hours. The precipitate was collected by filtration, washed with water and dried to give 4.5 g of 3-nitrobiphenyl-4-acetic acid as a cream colored solid.

Workup

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-f2ad746dbc44483f89f18ceefc5c67fb
Source dataset
uspto-grants-2003_03
Patent number
US06531502B1

Reaction notes

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