2,3-Dihydrobenzofuran-5-carboxaldehyde → 3-(2,3-Dihydrobenzofuran-5-ylmethylene)-5-fluoro-1,3-dihydroindol-2-one

HRID 1860797Notes

Reaction equation

HRID 1860797 reaction equation
[CH:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:10][CH2:9][CH2:8][C:7]=2[CH:11]=1)=O.[F:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])[CH2:16]2>>[O:10]1[C:6]2[CH:5]=[CH:4][C:3]([CH:1]=[C:16]3[C:15]4[C:19](=[CH:20][CH:21]=[C:13]([F:12])[CH:14]=4)[NH:18][C:17]3=[O:22])=[CH:11][C:7]=2[CH2:8][CH2:9]1

Participants

3

Reactant 2

HCID 7359012,3-Dihydrobenzofuran-5-carboxaldehydeHCID 37310125-fluoro-1,3-dihydro-2H-indol-2-one

Product 1

HCID 540227373-(2,3-Dihydrobenzofuran-5-ylmethylene)-5-fluoro-1,3-dihydroindol-2-one

Procedure

2,3-Dihydro-5-formylbenzofuran (commercially available) was condensed with 5-fluoro-2-oxindole to give 0.25 g of 3-(2,3-dihydrobenzofuran-5-ylmethylene)-5-fluoro-1,3-dihydroindol-2-one as a yellow-orange solid.

Sources & evidence

ORD record
ord-f1f9a4680714459f952981a953394a6f
Source dataset
uspto-grants-2003_03
Patent number
US06531502B1

Reaction notes

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