2-Oxindole-5-carboxylic acid → 3-(3,5-diisopropyl-4-methoxybenzylidene)-2-oxo-2,3-dihydro-1H-indole-5-carboxylic acid

HRID 1860854Notes

Reaction equation

HRID 1860854 reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]([CH:9]=[C:10]([CH:14]([CH3:16])[CH3:15])[C:11]=1[O:12][CH3:13])[CH:7]=O)([CH3:3])[CH3:2].[C:17]([C:20]1[CH:21]=[C:22]2[C:26](=[CH:27][CH:28]=1)[NH:25][C:24](=[O:29])[CH2:23]2)([OH:19])=[O:18]>>[CH:1]([C:4]1[CH:5]=[C:6]([CH:9]=[C:10]([CH:14]([CH3:16])[CH3:15])[C:11]=1[O:12][CH3:13])[CH:7]=[C:23]1[C:22]2[C:26](=[CH:27][CH:28]=[C:20]([C:17]([OH:19])=[O:18])[CH:21]=2)[NH:25][C:24]1=[O:29])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27733182-Oxindole-5-carboxylic acidHCID 105850253,5-Diisopropyl-4-methoxybenzaldehyde

Product 1

HCID 538563273-(3,5-diisopropyl-4-methoxybenzylidene)-2-oxo-2,3-dihydro-1H-indole-5-carboxylic acid

Procedure

3,5-Diisopropyl-4-methoxybenzaldehyde was condensed with 5-carboxy-2-oxindole to give 0.4 g of 3-(3,5-diisopropyl-4-methoxybenzylidene)-2-oxo-2,3-dihydro-1H-indole-5-carboxylic acid as a yellow-orange solid.

Sources & evidence

ORD record
ord-554214aefda045ef826615efab7a2565
Source dataset
uspto-grants-2003_03
Patent number
US06531502B1

Reaction notes

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