反应详情

温度

90 °C

4-(2-Carboxyethyl)-5-[6-(3-methoxyphenyl)-2-oxo-1,2-dihydroindol-3-ylidenemethyl]-3-methyl-1H-pyrrole-2-carboxylic acid (413 mg) suspended in ethylene glycol (5 mL) was held in ealed tube in a pre-heated oil bath at 200° C. for 2½ hours. The reaction mixture was cooled to 90° C. and potassium hydroxide (4 pellets) was added. It was then stirred at 100° C. for 2 more hours. The reaction mixture was cooled, poured into water and acidified with 2 N hydrochloric acid to pH 2. The precipitate was filtered, washed with water and dried in a vacuum oven overnight. The crude solid was purified on a silica gel column using 33:66:1 ethyl acetate:hexanes:glacial acetic acid as eluent to give 75 mg (20%) of 3-{2-[6-(3-methoxyphenyl)-2-oxo-1,2-dihydroindol-3-ylidenemethyl]-4-methyl-1H-pyrrol-3-yl}-propionic acid as an orange-red solid.

1. waitwas held in ealed tube in a pre-heated oil bath at 200° C. for 2½ hours
2. temperatureThe reaction mixture was cooled
3. filtrationThe precipitate was filtered
4. washwashed with water
5. customdried in a vacuum oven overnight
6. customThe crude solid was purified on a silica gel column