2-(Hydroxymethyl)anthraquinone → HCID 66738154, compound

HRID 1860958Notes

Reaction equation

HRID 1860958 reaction equation
[OH:1]C[C:3]1[CH:16]=[CH:15][C:14]2[C:13](=[O:17])[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6](=[O:18])[C:5]=2[CH:4]=1.C(CC[O:23][P:24]([N:32](C(C)C)C(C)C)N(C(C)C)C(C)C)#N.N1C=NN=N1>>[P:24]([NH2:32])([OH:23])[OH:1].[CH:8]1[C:7]2[C:6](=[O:18])[C:5]3[C:14](=[CH:15][CH:16]=[CH:3][CH:4]=3)[C:13](=[O:17])[C:12]=2[CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 3

HCID 870142-(Hydroxymethyl)anthraquinoneHCID 1281532-Cyanoethyl tetraisopropylphosphorodiamiditeHCID 178418441HCID 178418441, compound

Product 1

HCID 66738154HCID 66738154, compound

Procedure

Alternatively, reaction of 2-(hydroxymethyl)anthraquinone (4) with 2-cyanoethyl-N,N,N′,N′-tetraisopropylphosphorodiamidite and tetrazole afforded the phosphoramidite 5 as a bright yellow solid material after filtration and aqueous workup.

Sources & evidence

ORD record
ord-3f6d16f5c0274d46a3928100b7bd741a
Source dataset
uspto-grants-2003_03
Patent number
US06531591B1

Reaction notes

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