Hydrogen Bromide → 1,3-Di-n-butyl-8-bromo Xanthine

HRID 1860969Notes

Reaction equation

[CH2:1]([N:5]1[C:14](=[O:15])[C:13]2[NH:12][C:11]([N+]([O-])=O)=[N:10][C:9]=2[N:8]([CH2:19][CH2:20][CH2:21][CH3:22])[C:6]1=[O:7])[CH2:2][CH2:3][CH3:4].[BrH:23]>>[CH2:1]([N:5]1[C:14](=[O:15])[C:13]2[NH:12][C:11]([Br:23])=[N:10][C:9]=2[N:8]([CH2:19][CH2:20][CH2:21][CH3:22])[C:6]1=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 99444751,3-Di-n-butyl-8-nitro Xanthine

Product 1

HCID 101544891,3-Di-n-butyl-8-bromo Xanthine

Procedure

1,3Di-n-butyl-8-bromo xanthine was prepared from 1,3-di-n-butyl-8-nitro xanthine (0.5 g, 0.0016 mol) and concentrated hydrobromic acid (8 ml) using the procedure was described in Example 15. The title product was obtained after recrystallisation from ethanol, yield 0.4 g (91%), m.pt. 178° C.

Sources & evidence

ORD record: ord-a87358fdd59d41769da8b3573740ae0c
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06531600B1

Reaction notes

Loading…