2-Chloropyridine-3-sulfonyl chloride → Isobutyl (2-chloropyridin-3-yl)sulfonyl(3-methoxy-5-methylpyrazin-2-yl)carbamate

HRID 1861027Notes

Reaction equation

HRID 1861027 reaction equation
[Cl:1][C:2]1[C:7]([S:8](Cl)(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:12][O:13][C:14]1[C:15]([NH:21][C:22](=[O:28])[O:23][CH2:24][CH:25]([CH3:27])[CH3:26])=[N:16][CH:17]=[C:18]([CH3:20])[N:19]=1>>[Cl:1][C:2]1[C:7]([S:8]([N:21]([C:22]([O:23][CH2:24][CH:25]([CH3:27])[CH3:26])=[O:28])[C:15]2[C:14]([O:13][CH3:12])=[N:19][C:18]([CH3:20])=[CH:17][N:16]=2)(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 102199682-Chloropyridine-3-sulfonyl chlorideHCID 10889995Isobutyl (3-methoxy-5-methylpyrazin-2-yl)carbamate

Product 1

HCID 11015197Isobutyl (2-chloropyridin-3-yl)sulfonyl(3-methoxy-5-methylpyrazin-2-yl)carbamate

Procedure

reaction of 2-chloropyridine-3-sulfonyl chloride with isobutyl N-(3-methoxy-5-methylpyrazin-2-yl)carbamate in the presence of an alkali metal hydride in an inert solvent to give 2-chloro-N-isobutoxycarbonyl-N-(3-methoxy-5-methylpyrazin-2-yl)pyridine-3-sulfonamide;

Sources & evidence

ORD record
ord-8cfe341ce247446f94cdcccae494d38a
Source dataset
uspto-grants-2003_03
Patent number
US06531605B1

Reaction notes

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