2,6-Dimethyl-4-heptanol → HCID 13605067, compound

HRID 1861218Notes

Reaction equation

HRID 1861218 reaction equation
[CH3:1][CH:2]([CH2:4][CH:5]([OH:10])[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:3].C(N(CC)CC)C.[CH3:18][S:19](Cl)(=[O:21])=[O:20]>C(Cl)(Cl)Cl>[CH3:18][S:19]([O:10][CH:5]([CH2:6][CH:7]([CH3:9])[CH3:8])[CH2:4][CH:2]([CH3:3])[CH3:1])(=[O:21])=[O:20]

Participants

5

Reactant 3

HCID 79572,6-Dimethyl-4-heptanolHCID 8471TriethylamineHCID 31297Methanesulfonyl chloride

Product 1

HCID 13605067HCID 13605067, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
0 °C

Procedure

In a one liter three-neck flask was mixed 100 g (0.69 moles) of 2,6-dimethyl-4-heptanol and 580 g chloroform. Triethylamine (77.1 g; 6 moles) was added and the reaction mixture cooled to 0° C. Methanesulfonyl chloride (83.4 g; 0.73 moles) was added dropwise, keeping the reaction temperature about 0° C. After holding at about 0° C. for one hour, gas chromatograph (GC) showed less than 5% residual alcohol.

Workup

  1. customthe reaction temperature about 0° C

Sources & evidence

ORD record
ord-85c674aa01014f7fa1c082cec9c62516
Source dataset
uspto-grants-2003_03
Patent number
US06531613B1

Reaction notes

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