反应详情

BAL resin immobilized 5-(S)-acetamidomethyl-3-[4′dimethoxymethyl-3′-fluorophenyl]-oxazolidine-2-one (0.100 g, 0.029 mmol) was suspended in 60% trifluoroacetic acid in dichloromethane (2 ml) for 2 h at room temperature. The mixture was filtered, and supernatant was evaporated under vacuum to give the crude product. The crude product was purified by preparative HPLC to afford the desired product as an oil. Yield 4.9 mg, (60%). Rt 3.0 min. MS (m/z): 281.1 [M+H]+. 1H NMR.

1. filtrationThe mixture was filtered
2. customsupernatant was evaporated under vacuum
3. customto give the crude product
4. customThe crude product was purified by preparative HPLC