Potassium Carbonate → 1-Ethynyl-4-(1-methoxycyclopropyl)-benzene

HRID 1861393Notes

Reaction equation

HRID 1861393 reaction equation
[CH3:1][O:2][C:3]1([C:6]2[CH:11]=[CH:10][C:9]([C:12]#[C:13][Si](C)(C)C)=[CH:8][CH:7]=2)[CH2:5][CH2:4]1.C(=O)([O-])[O-].[K+].[K+]>CO>[C:12]([C:9]1[CH:10]=[CH:11][C:6]([C:3]2([O:2][CH3:1])[CH2:4][CH2:5]2)=[CH:7][CH:8]=1)#[CH:13]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 22568890[4-(1-Methoxycyclopropyl)phenylethynyl]-trimethylsilane2×

Product 1

HCID 225689501-Ethynyl-4-(1-methoxycyclopropyl)-benzene

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [4-(1-methoxycyclopropyl)phenylethynyl]-trimethylsilane (Intermediate 60, 285.0 mg, 1.18 mmols) in methanol (10 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (220 mg, 100%) was used directly in the next reaction.

Sources & evidence

ORD record
ord-15408c9c958046498607ceef74149a29
Source dataset
uspto-grants-2003_03
Patent number
US06531599B2

Reaction notes

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