Potassium Carbonate → HCID 22568804, compound

HRID 1861484Notes

Reaction equation

HRID 1861484 reaction equation
[CH3:1][C:2]1[CH:13]=[C:12]([C:14]#[C:15][Si](C)(C)C)[CH:11]=[CH:10][C:3]=1[CH2:4][N:5]1[CH:9]=[CH:8][N:7]=[CH:6]1.C(=O)([O-])[O-].[K+].[K+]>CO>[C:14]([C:12]1[CH:11]=[CH:10][C:3]([CH2:4][N:5]2[CH:9]=[CH:8][N:7]=[CH:6]2)=[C:2]([CH3:1])[CH:13]=1)#[CH:15]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 225689641-(2-Methyl-4-trimethylsilanylethynyl-benzyl)-1H-imidazole2×

Product 1

HCID 22568804HCID 22568804, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; 1-(2-methyl-4-trimethylsilanylethynyl-benzyl)-1H-imidazole (Intermediate 140, 140.0 mg, 0.53 mmols) in methanol (5 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (105 mg, 100%) was used directly in the next reaction.

Sources & evidence

ORD record
ord-dba4885262704715bbda026f58a44661
Source dataset
uspto-grants-2003_03
Patent number
US06531599B2

Reaction notes

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