2-Vinylpyridine → HCID 12721944, compound

HRID 1861619Notes

Reaction equation

HRID 1861619 reaction equation
[C:1]([CH2:4][C:5](=O)[CH3:6])(=[O:3])[CH3:2].[Na].C([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)=C>>[N:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[CH2:6][CH2:5][CH2:4][C:1](=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 75212-VinylpyridineHCID 31261AcetylacetoneHCID 5360545Sodium

Product 1

HCID 12721944HCID 12721944, compoundYield 14.6%

Procedure

According to reference F. Noel, Albertson J. Am. Chem. Soc. 1950, 72, 2594-99, a reaction mixture comprising 50 g of acetyl acetone, 1.5 g of sodium and 108 g of 2-vinylpyridine is refluxed for 7 hours. The produced may be distilled as a yellow oil at 1.5. 102 Pa (1.1 Torr) (b.p.: 90-127° C.). Fractional distillation of this oil yields 11.9 g of 5-(2-pyridyl)-2-pentanone (4a) with a boiling point of 88-105° C. and 1.3·102 Pa (1.0 Torr).

Workup

  1. customThe produced may
  2. distillationbe distilled as a yellow oil at 1.5
  3. distillationFractional distillation of this oil

Sources & evidence

ORD record
ord-cd81a12cc33c472aa3a914159b44b7a0
Source dataset
uspto-grants-2003_03
Patent number
US06534489B1

Reaction notes

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