反应详情

To a solution of thiazolo [5,4-c]pyridine-2-carboxylic acid ethyl ester (16 mg, 0.08 mmol) and 1(R)-phenyl ethyl amine (0.03 mL, 0.23 mmol) in dichloromethane(0.3 mL)was added a solution of trimethylaluminum in hexane(0.115 mL, 2.0 M., 0.23 mmol). The solution was then stirred for 5 hours at room temperature. After usual work-up, the product was purified by flash chromatography (CH2Cl2/EtOAc 1:1)and triturated in hexane to give 14 mg of the thiazolo derivative.

1. customAfter usual work-up, the product was purified by flash chromatography (CH2Cl2/EtOAc 1:1)and
2. customtriturated in hexane
3. customto give 14 mg of the thiazolo derivative