反应详情

A mixture of the compound (1.0 g) obtained in Example 248, N-bromosuccinimide (698 mg), α,α′-azobis(isobutyronitrile) (catalytic amount) and carbon tetrachloride (20 ml) was heated under reflux for 16 h. The reaction mixture was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent, n-hexane:ethyl acetate=8:2) to give 605 mg of the titled compound (yield, 46%).

1. temperaturewas heated
2. temperatureunder reflux for 16 h
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. customthe resulting residue was purified by silica gel column chromatography (eluent, n-hexane:ethyl acetate=8:2)