反应详情

To a solution of the compound (164 mg) obtained in Example 250 in methanol (5 ml), hydrazine monohydrate (0.057 ml) was added and heated under reflux for 3 h. The reaction mixture was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent, n-hexane:ethyl acetate=6:4) to give 67 mg of the titled compound (yield, 76%).

1. temperatureheated
2. temperatureunder reflux for 3 h
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. customthe resulting residue was purified by silica gel column chromatography (eluent, n-hexane:ethyl acetate=6:4)