Potassium Carbonate → N-(1-(2-benzyloxy-5-nitrophenyl)-1-methylethyl)carbamic acid t-butyl ester

HRID 1861970Notes

Reaction equation

[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][C:10]=1[C:18]([NH2:21])([CH3:20])[CH3:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:22](=[O:25])([O-])[O-:23].[K+].[K+]>>[C:2]([O:23][C:22](=[O:25])[NH:21][C:18]([C:10]1[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:9]=1[O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)([CH3:19])[CH3:20])([CH3:7])([CH3:3])[CH3:1]

Participants

Reactant 2

HCID 11430Potassium Carbonate

HCID 18622160N-(1-(2-benzyloxy-5-nitrophenyl)-1-methylethyl)amine

Product 1

HCID 22981078N-(1-(2-benzyloxy-5-nitrophenyl)-1-methylethyl)carbamic acid t-butyl esterYield 94%

Procedure

Using the compound obtained in Example 564 as a starting material and also using potassium carbonate as a base, the same procedure of Example 63 gave 828 mg of the titled compound (yield, 94%).

Sources & evidence

ORD record: ord-02d8afce28c14828b0020e2ac78f36ea
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06534546B1

Reaction notes

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