Pyrrolidine → HCID 22981346, compound

HRID 1861972Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:9][C:10]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:11]=1F)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH:27]1[CH2:31][CH2:30][CH2:29][CH2:28]1>>[C:1]([O:5][C:6]([N:8]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:9][C:10]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:11]=1[N:27]1[CH2:31][CH2:30][CH2:29][CH2:28]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 22981229HCID 22981229, compound

Product 1

HCID 22981346HCID 22981346, compoundYield 80%

Procedure

Using the compound obtained in Example 263 as a starting material and also using pyrrolidine as a reagent, the same procedure of Example 264 gave the titled compound (yield, 80%).

Sources & evidence

ORD record: ord-b4e3450f49db4f71a2d54f2802d0cc55
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06534546B1

Reaction notes

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